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Agency for Care Effectiveness Established by the Ministry of Health, ACE is Singapore's national health technology assessment (HTA) and clinical guidelines agency helping providers, patients and payers. This ACE Clinical Guideline (ACG) provides guidance on diagnosis, severity assessment and management of mild and moderate atopic dermatitis (AD), including topical and non. View all ACE Clinical Guidelines (ACGs) and other local guidelines validated by ACE. This ACE Clinical Guideline (ACG) provides evidence-based recommendations on risk assessment, timely diagnosis, optimal treatment, and indications for specialist referral in adults with osteoporosis.